Issue 18, 2011
From the journal:

Soft Matter

In situ characterization of lipidic bupivacaine-loaded formulations

Anan Yaghmur,*a   Susan Weng Larsen,a   Mechthild Schmitt,bd   Jesper Østergaard,a   Claus Larsen,a   Henrik Jensen,a   Arto Urttib  and  Michael Rappolt*c  

* Corresponding authors

a Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark
E-mail: aya@farma.ku.dk
Fax: +45 35336030
Tel: +45 35 33 65 41

b Centre for Drug Research University of Helsinki, P.O. Box 56, Helsinki, Finland

c Institute of Biophysics and Nanosystems Research, Austrian Academy of Sciences, Graz, Austria
E-mail: michael.rappolt@oeaw.ac.at

d Division of Biopharmacy and Pharmacokinetics, University of Helsinki, P.O. Box 56, Helsinki, Finland

Abstract

This work details the in situ dynamical behaviour of local anaesthetic bupivacaine (BUP)-loaded L2 and H2 phase precursors (preformulations of BUP) upon rapid exposure to phosphate buffer under physiological conditions (pH 7.4, 37 °C). The hydration-induced structural transitions are characterized by time-resolved synchrotron SAXS.

Graphical abstract: In situ characterization of lipidic bupivacaine-loaded formulations

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Article information

DOI
https://doi.org/10.1039/C1SM05854A
Article type
Paper
Submitted
09 May 2011
Accepted
22 Jun 2011
First published
03 Aug 2011

Soft Matter, 2011,7, 8291-8295

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In situ characterization of lipidic bupivacaine-loaded formulations

A. Yaghmur, S. W. Larsen, M. Schmitt, J. Østergaard, C. Larsen, H. Jensen, A. Urtti and M. Rappolt, Soft Matter, 2011, 7, 8291 DOI: 10.1039/C1SM05854A

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