Issue 2, 2012
From the journal:

Analytical Methods

Mass spectrometric identification and characterization of new toremifene metabolites in human urine by liquid chromatography quadrupole/time-of-flight tandem mass spectrometry (LC-QTOFMS)

Jianghai Lu,*a   Genye He,a   Xiaobing Wang,a   Youxuan Xu,a   Yun Wu,a   Ying Dong,a   Moutian Wua  and  Gangfeng Ouyang*b  

* Corresponding authors

a National Anti-Doping Laboratory, China Anti-Doping Agency, 1st Anding Road, ChaoYang District, Beijing, P. R. China
E-mail: jxxyg@yahoo.com.cn
Fax: +86-20-84110953
Tel: +86-20-84110953

b KLGHEI of Environment and Energy Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China
E-mail: cesoygf@mail.sysu.edu.cn
Fax: +86-20-84110953
Tel: +86-20-84110953

Abstract

Urine samples after oral administration of toremifene were investigated by liquid chromatography quadrupole time-of-flight tandem mass spectrometry (LC-QTOFMS) with accurate mass measurement. Two new metabolites were detected in positive full scan and targeted MS/MS experiments and their chemical structures were characterized as: 3-methoxy-4,4′-dihydroxy-toremifene and 4-hydroxy-N-oxide-toremifene. As the two metabolites could be detected in all urine samples during one week after intake, they should be potential biomarkers for monitoring the oral administration of toremifene in doping analysis.

Graphical abstract: Mass spectrometric identification and characterization of new toremifene metabolites in human urine by liquid chromatography quadrupole/time-of-flight tandem mass spectrometry (LC-QTOFMS)

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Article information

DOI
https://doi.org/10.1039/C2AY05702F
Article type
Paper
Submitted
21 Oct 2011
Accepted
30 Nov 2011
First published
22 Dec 2011

Anal. Methods, 2012,4, 439-443

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Mass spectrometric identification and characterization of new toremifene metabolites in human urine by liquid chromatography quadrupole/time-of-flight tandem mass spectrometry (LC-QTOFMS)

J. Lu, G. He, X. Wang, Y. Xu, Y. Wu, Y. Dong, M. Wu and G. Ouyang, Anal. Methods, 2012, 4, 439 DOI: 10.1039/C2AY05702F

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