Issue 2, 2012
From the journal:

Chemical Communications

Inhibition of TNF-α stimulated nuclear factor-kappa B (NF-κB) activation by cyclometalated platinum(ii) complexes†

Jia Liu,a   Raymond Wai-Yin Sun,a   Chung-Hang Leung,a   Chun-Nam Loka  and  Chi-Ming Che*a  

* Corresponding authors

a Department of Chemistry, State Key Laboratory of Synthetic Chemistry, and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong
E-mail: cmche@hku.hk
Fax: +852 2857 1586
Tel: +852 2857 2154

Abstract

Cyclometalated platinum(II) complexes [PtII(C∧N∧N)(C[triple bond, length as m-dash]NR)]+ (HC∧N∧N = 6-phenyl-2,2′-bipyridyl) display significant inhibition towards TNF-α stimulated NF-κB-dependent gene transcription at concentrations down to the micromolar range.

Graphical abstract: Inhibition of TNF-α stimulated nuclear factor-kappa B (NF-κB) activation by cyclometalated platinum(ii) complexes

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Article information

DOI
https://doi.org/10.1039/C1CC15317J
Article type
Communication
Submitted
26 Aug 2011
Accepted
01 Nov 2011
First published
16 Nov 2011

Chem. Commun., 2012,48, 230-232

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Inhibition of TNF-α stimulated nuclear factor-kappa B (NF-κB) activation by cyclometalated platinum(II) complexes

J. Liu, R. W. Sun, C. Leung, C. Lok and C. Che, Chem. Commun., 2012, 48, 230 DOI: 10.1039/C1CC15317J

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