Issue 13, 2012
From the journal:

Chemical Communications

Dual anticancer activity in a single compound: visible-light-induced apoptosis by an antiangiogenic iridium complex†

Anja Kastl,a   Alexander Wilbuer,a   Anna Lena Merkel,b   Li Feng,a   Pietro Di Fazio,b   Matthias Ockerb  and  Eric Meggers*a  

* Corresponding authors

a Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Straße, 35043 Marburg, Germany
E-mail: meggers@chemie.uni-marburg.de
Fax: +49 6421 2822189
Tel: +49 6421 2821534

b Institut für Chirurgische Forschung, Philipps-Universität Marburg, Baldingerstraße, 35043 Marburg, Germany

Abstract

A metal complex is identified in which the metal fulfills two independent functions: as a structural scaffold for the specific molecular recognition of protein kinases resulting in antiangiogenic properties, together with a visible-light-induced photoreactivity triggering apopotosis in cancer cells.

Graphical abstract: Dual anticancer activity in a single compound: visible-light-induced apoptosis by an antiangiogenic iridium complex

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Article information

DOI
https://doi.org/10.1039/C1CC15378A
Article type
Communication
Submitted
29 Aug 2011
Accepted
19 Oct 2011
First published
07 Nov 2011

Chem. Commun., 2012,48, 1863-1865

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Dual anticancer activity in a single compound: visible-light-induced apoptosis by an antiangiogenic iridium complex

A. Kastl, A. Wilbuer, A. L. Merkel, L. Feng, P. Di Fazio, M. Ocker and E. Meggers, Chem. Commun., 2012, 48, 1863 DOI: 10.1039/C1CC15378A

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