Issue 1, 2012
From the journal:

Chemical Communications

Metal to ligand charge transfer induced DNA photobinding in a Ru(ii)–Pt(ii) supramolecule using red light in the therapeutic window: a new mechanism for DNA modification†

Samantha L. H. Higgins,a   Allison J. Tucker,a   Brenda S. J. Winkelb  and  Karen J. Brewer*a  

* Corresponding authors

a Virginia Polytechnic Institute and State University, Department of Chemistry, Blacksburg, VA, USA
E-mail: k.brewer@vt.edu
Tel: 540-231-6579

b Virginia Polytechnic Institute and State University, Department of Biological Sciences, Blacksburg, VA, USA

Abstract

The Ru(II)–Pt(II) supramolecular complex, [(Ph2phen)2Ru(dpp)PtCl2]2+, displays a new mechanism for DNA modification: photobinding through a 3MLCT excited state. Gel shift analysis, selective DNA precipitation, and DNA melting point experiments support efficient covalent DNA binding following visible light excitation.

Graphical abstract: Metal to ligand charge transfer induced DNA photobinding in a Ru(ii)–Pt(ii) supramolecule using red light in the therapeutic window: a new mechanism for DNA modification

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Article information

DOI
https://doi.org/10.1039/C1CC15780A
Article type
Communication
Submitted
18 Sep 2011
Accepted
14 Oct 2011
First published
10 Nov 2011

Chem. Commun., 2012,48, 67-69

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Metal to ligand charge transfer induced DNA photobinding in a Ru(II)–Pt(II) supramolecule using red light in the therapeutic window: a new mechanism for DNA modification

S. L. H. Higgins, A. J. Tucker, B. S. J. Winkel and K. J. Brewer, Chem. Commun., 2012, 48, 67 DOI: 10.1039/C1CC15780A

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