Issue 6, 2012
From the journal:

Chemical Communications

A multi-component domino reaction for the direct access to polyfunctionalized indolesvia intermolecular allylic esterification and indolation†

Bo Jiang,a   Mian-Shuai Yi,a   Feng Shi,a   Shu-Jiang Tu,*a   Suresh Pindi,b   Patrick McDowellb  and  Guigen Li*b  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Xuzhou Normal University, P. R. China
E-mail: laotu@xznu.edu.cn

b Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, USA
E-mail: guigen.li@ttu.edu

Abstract

A novel multi-component reaction for the synthesis of polyfunctionalized indoles and bis-indoles has been established. The reaction pathways were controlled by varying enamines with different substitution patterns to give polyfunctionalized indoles and bis-indoles selectively. The reaction proceeds at a fast speed within 15–30 min with water as the major byproduct, which makes work-up convenient.

Graphical abstract: A multi-component domino reaction for the direct access to polyfunctionalized indolesvia intermolecular allylic esterification and indolation

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Article information

DOI
https://doi.org/10.1039/C1CC15913E
Article type
Communication
Submitted
23 Sep 2011
Accepted
18 Oct 2011
First published
31 Oct 2011

Chem. Commun., 2012,48, 808-810

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A multi-component domino reaction for the direct access to polyfunctionalized indolesvia intermolecular allylic esterification and indolation

B. Jiang, M. Yi, F. Shi, S. Tu, S. Pindi, P. McDowell and G. Li, Chem. Commun., 2012, 48, 808 DOI: 10.1039/C1CC15913E

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