Issue 4, 2012
From the journal:

Chemical Communications

The reverse of polymer degradation: in situ crosslinked gel formation through disulfide cleavage†

Aram O. Saeed,‡§a   Ben Newland,‡a   Abhay Pandit*a  and  Wenxin Wang*a  

* Corresponding authors

a Network of Excellence for Functional Biomaterials, National University of Ireland Galway, IDA Business Park, Galway, Ireland
E-mail: wenxin.wang@nuigalway.ie, abhay.pandit@nuigalway.ie
Fax: +353 (0)91 49 5585
Tel: +353 91 49 2758

Abstract

In contrast to the usual inclusion of disulfide bonds within a polymer structure to facilitate bio-degradation, we have designed a self-curing “one pot” hyperbranched polymer capable of forming crosslinked gels under reducing conditions abundant in tumoural tissue.

Graphical abstract: The reverse of polymer degradation: in situ crosslinked gel formation through disulfide cleavage

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Article information

DOI
https://doi.org/10.1039/C1CC16538K
Article type
Communication
Submitted
20 Oct 2011
Accepted
10 Nov 2011
First published
11 Nov 2011

Chem. Commun., 2012,48, 585-587

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The reverse of polymer degradation: in situ crosslinked gel formation through disulfide cleavage

A. O. Saeed, B. Newland, A. Pandit and W. Wang, Chem. Commun., 2012, 48, 585 DOI: 10.1039/C1CC16538K

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