Issue 27, 2012
From the journal:

Chemical Communications

Isotope-coded, fluorous photoaffinity labeling reagents†

Zhiquan Song,a   Weigang Huanga  and  Qisheng Zhang*a  

* Corresponding authors

a Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, USA
E-mail: qszhang@unc.edu

Abstract

A pair of isotope-coded, fluorous photoaffinity labeling reagents has been developed and coupled with a peptide. The modified peptides form adducts with methanol upon light illumination, which show characteristic isotope labeling patterns in mass spectra and can be separated from other peptides through fluorous silica.

Graphical abstract: Isotope-coded, fluorous photoaffinity labeling reagents

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Article information

DOI
https://doi.org/10.1039/C2CC00027J
Article type
Communication
Submitted
02 Jan 2012
Accepted
14 Feb 2012
First published
14 Feb 2012

Chem. Commun., 2012,48, 3339-3341

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Isotope-coded, fluorous photoaffinity labeling reagents

Z. Song, W. Huang and Q. Zhang, Chem. Commun., 2012, 48, 3339 DOI: 10.1039/C2CC00027J

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