Issue 20, 2012

Simplifying native chemical ligation with an N-acylsulfonamide linker

Abstract

We report a simplified procedure for the chemical ligation of peptides by using the sulfamylbutyryl linker as a mildly activating group capable of participating in ligation. When the peptidyl N-methylsulfonamide is directly added with excess thiols to ligation reactions, the speed of reaction is comparable to native chemical ligation.

Graphical abstract: Simplifying native chemical ligation with an N-acylsulfonamide linker

Supplementary files

Article information

Article type
Communication
Submitted
22 Sep 2011
Accepted
11 Jan 2012
First published
31 Jan 2012

Chem. Commun., 2012,48, 2579-2581

Simplifying native chemical ligation with an N-acylsulfonamide linker

F. Burlina, C. Morris, R. Behrendt, P. White and J. Offer, Chem. Commun., 2012, 48, 2579 DOI: 10.1039/C2CC15911B

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