Issue 13, 2012

Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations

Abstract

The zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1) is inhibited by several classes of zinc-binders (sulfonamides, sulfamates, and sulfamides) as well as by compounds which do not interact with the metal ion (phenols, polyamines and coumarins). Here we report a new class of potent CA inhibitors which bind the zinc ion: the dithiocarbamates (DTCs). They coordinate to the zinc ion from the enzyme active site in monodentate manner and establish many favorable interactions with amino acid residues nearby. Several low nanomolar CA I, II and IX inhibitors were detected.

Graphical abstract: Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations

Supplementary files

Article information

Article type
Communication
Submitted
14 Oct 2011
Accepted
12 Dec 2011
First published
14 Dec 2011

Chem. Commun., 2012,48, 1868-1870

Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations

F. Carta, M. Aggarwal, A. Maresca, A. Scozzafava, R. McKenna and C. T. Supuran, Chem. Commun., 2012, 48, 1868 DOI: 10.1039/C2CC16395K

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