Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations†
Abstract
The zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1) is inhibited by several classes of zinc-binders (
* Corresponding authors
a
Università degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm. 188, Via della Lastruccia 3, I-50019 Sesto Fiorentino (Firenze), Italy
E-mail:
claudiu.supuran@unifi.it
b
Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Box 100245, Gainesville, USA
E-mail:
rmckenna@ufl.edu
Fax: +1 352 392-3422
Tel: +1 352 392-5696
The zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1) is inhibited by several classes of zinc-binders (
F. Carta, M. Aggarwal, A. Maresca, A. Scozzafava, R. McKenna and C. T. Supuran, Chem. Commun., 2012, 48, 1868 DOI: 10.1039/C2CC16395K
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