Issue 30, 2012

Could hydrolysis of arsenic substituted DNA be prevented? Protection arises from stacking interactions

Abstract

Investigation of the hydrolysis of dinucleoside-arsenate-deoxyguanylyl-3′,5′-deoxyguanosine (dGAsdG) reveals that base-stacking in DNA increases the resistance of As–DNA towards hydrolysis. Base-stacking raises the activation energy of hydrolysis. Hydrolysis of As–DNA is found to be endothermic. The hydrolysis stability of As–DNA should be higher than that estimated based on arsenate diester models.

Graphical abstract: Could hydrolysis of arsenic substituted DNA be prevented? Protection arises from stacking interactions

Supplementary files

Article information

Article type
Communication
Submitted
24 Oct 2011
Accepted
16 Feb 2012
First published
17 Feb 2012

Chem. Commun., 2012,48, 3626-3628

Could hydrolysis of arsenic substituted DNA be prevented? Protection arises from stacking interactions

J. Wang, J. Gu and J. Leszczynski, Chem. Commun., 2012, 48, 3626 DOI: 10.1039/C2CC16600C

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