Issue 14, 2012
From the journal:

Chemical Communications

Intramolecular folding in three tandem guanine repeats of human telomeric DNA†

Deepak Koirala,a   Tomoko Mashimo,b   Yuta Sannohe,b   Zhongbo Yu,a   Hanbin Mao*a  and  Hiroshi Sugiyama*bcd  

* Corresponding authors

a Department of Chemistry & Biochemistry, Kent State University, Kent, USA
E-mail: hmao@kent.edu

b Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan

c Institute for Integrated Cell Material Sciences (iCeMS), Kyoto University, Yoshida-ushinomiyacho, Sakyo-ku, Kyoto 606-8501, Japan

d CREST, Japan Science and Technology Corporation (JST), Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan
E-mail: hs@kuchem.kyoto-u.ac.jp

Abstract

Intramolecular folding in three tandem guanine repeats of human telomeric DNA has been investigated using optical-tweezers, MD simulation and circular dichroism. A mechanically and thermodynamically stable species in this sequence shows a structure consistent with a triplex conformation. A similar species has also been observed to coexist with a G-quadruplex in a DNA sequence with four tandem guanine repeats.

Graphical abstract: Intramolecular folding in three tandem guanine repeats of human telomeric DNA

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Article information

DOI
https://doi.org/10.1039/C2CC16752B
Article type
Communication
Submitted
01 Nov 2011
Accepted
13 Dec 2011
First published
14 Dec 2011

Chem. Commun., 2012,48, 2006-2008

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Intramolecular folding in three tandem guanine repeats of human telomeric DNA

D. Koirala, T. Mashimo, Y. Sannohe, Z. Yu, H. Mao and H. Sugiyama, Chem. Commun., 2012, 48, 2006 DOI: 10.1039/C2CC16752B

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