Issue 8, 2012

Potent and selective inhibition of T-cell proteintyrosine phosphatase (TCPTP) by a dinuclear copper(ii) complex

Abstract

A dinuclear Cu(II) complex, [Cu2(μ-IDA)(phen)3(NO3)]NO3·4H2O (phen = 1,10-phenanthroline, H2IDA = iminodiacetic acid), was found to potently and selectively inhibit T-cell protein tyrosine phosphatase, and lead to the anti-proliferation and apoptosis of C6 glioma cells.

Graphical abstract: Potent and selective inhibition of T-cell protein tyrosine phosphatase (TCPTP) by a dinuclear copper(ii) complex

Supplementary files

Article information

Article type
Communication
Submitted
03 Nov 2011
Accepted
25 Nov 2011
First published
25 Nov 2011

Chem. Commun., 2012,48, 1153-1155

Potent and selective inhibition of T-cell protein tyrosine phosphatase (TCPTP) by a dinuclear copper(II) complex

C. Yuan, M. Zhu, Q. Wang, L. Lu, S. Xing, X. Fu, Z. Jiang, S. Zhang, Z. Li, Z. Li, R. Zhu, L. Ma and L. Xu, Chem. Commun., 2012, 48, 1153 DOI: 10.1039/C2CC16818A

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