Issue 8, 2012
From the journal:

Chemical Communications

Chemiluminescence biosensors for DNA detection using graphene oxide and a horseradish peroxidase-mimicking DNAzyme†

Ming Luo,a   Xi Chen,a   Guohua Zhou,a   Xia Xiang,a   Lu Chen,a   Xinghu Jia  and  Zhike He*a  

* Corresponding authors

a Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China
E-mail: zhkhe@whu.edu.cn
Fax: +86-27-6875-4067
Tel: +86-27-6875-6557

Abstract

In this communication, we demonstrate that graphene oxide (GO) greatly inhibits the peroxidatic activity of a horseradish peroxidase-mimicking DNAzyme. Combining this observation with the unique DNA/GO interactions, an ultrasensitive GO-based chemiluminescence DNA biosensing platform is developed.

Graphical abstract: Chemiluminescence biosensors for DNA detection using graphene oxide and a horseradish peroxidase-mimicking DNAzyme

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Article information

DOI
https://doi.org/10.1039/C2CC16868E
Article type
Communication
Submitted
06 Nov 2011
Accepted
21 Nov 2011
First published
24 Nov 2011

Chem. Commun., 2012,48, 1126-1128

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Chemiluminescence biosensors for DNA detection using graphene oxide and a horseradish peroxidase-mimicking DNAzyme

M. Luo, X. Chen, G. Zhou, X. Xiang, L. Chen, X. Ji and Z. He, Chem. Commun., 2012, 48, 1126 DOI: 10.1039/C2CC16868E

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