Issue 8, 2012
From the journal:

Chemical Communications

Development of the first sphingomyelin biomimetic stationary phase for immobilized artificial membrane (IAM) chromatography†

Dieter Verzele,a   Frédéric Lynen,a   Mike De Vrieze,a   Adrian G. Wright,b   Melissa Hanna-Brownb  and  Pat Sandra*ac  

* Corresponding authors

a Pfizer Analytical Research Centre, Department of Organic Chemistry, Ghent University, Krijgslaan 281-S4bis, B-9000 Ghent, Belgium
E-mail: pat.sandra@ugent.be
Fax: +32 9 264 4998
Tel: +32 9 264 9608

b Pfizer Global R&D Laboratories, Analytical Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK
E-mail: melissa.hanna-brown@pfizer.com
Tel: +44 (0)1304 642125

c Research Institute for Chromatography, Kennedypark 26, B-8500 Kortrijk, Belgium
E-mail: pat.sandra@richrom.com
Fax: +32 56 204859
Tel: +32 56 204031

Abstract

A prototype sphingomyelin stationary phase for Immobilized Artificial Membrane (IAM) chromatography was synthesized by an ultra-short, solid-phase inspired methodology, in which an oxidative release monitoring strategy played a vital role. Evaluated in a proof-of-concept model for blood–brain barrier passage, partial least squares regression demonstrated its potential as an in vitro prediction tool.

Graphical abstract: Development of the first sphingomyelin biomimetic stationary phase for immobilized artificial membrane (IAM) chromatography

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Article information

DOI
https://doi.org/10.1039/C2CC16872C
Article type
Communication
Submitted
06 Nov 2011
Accepted
29 Nov 2011
First published
29 Nov 2011

Chem. Commun., 2012,48, 1162-1164

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Development of the first sphingomyelin biomimetic stationary phase for immobilized artificial membrane (IAM) chromatography

D. Verzele, F. Lynen, M. D. Vrieze, A. G. Wright, M. Hanna-Brown and P. Sandra, Chem. Commun., 2012, 48, 1162 DOI: 10.1039/C2CC16872C

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