Issue 23, 2012
From the journal:

Chemical Communications

Spontaneous inter-conversion of insulin fibril chirality†

Dmitry Kurouski,a   Rina K. Dukor,b   Xuefang Lu,b   Laurence A. Nafiebc  and  Igor K. Lednev*a  

* Corresponding authors

a Department of Chemistry, University at Albany, SUNY, 1400 Washington Ave., Albany, USA
E-mail: ilednev@albany.edu

b BioTools, Inc., 17546 Bee Line Hwy, Jupiter, Florida, USA
E-mail: rkdukor@aol.com

c Department of Chemistry, Syracuse University, Syracuse, New York, USA
E-mail: lnafie@syr.edu

Abstract

Amyloid fibrils are associated with many neurodegenerative diseases and are considered to be the energetically most favorable form of proteins. Here we report that a small pH change initiates spontaneous transformation of insulin fibrils from one polymorph to another. As a result, fibril supramolecular chirality overturns both accompanying morphological and structural changes.

Graphical abstract: Spontaneous inter-conversion of insulin fibril chirality

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Article information

DOI
https://doi.org/10.1039/C2CC16895B
Article type
Communication
Submitted
07 Nov 2011
Accepted
14 Dec 2011
First published
14 Dec 2011

Chem. Commun., 2012,48, 2837-2839

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Spontaneous inter-conversion of insulin fibril chirality

D. Kurouski, R. K. Dukor, X. Lu, L. A. Nafie and I. K. Lednev, Chem. Commun., 2012, 48, 2837 DOI: 10.1039/C2CC16895B

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