Issue 11, 2012
From the journal:

Chemical Communications

Creation of an artificial metalloprotein with a Hoveyda–Grubbs catalyst moiety through the intrinsic inhibition mechanism of α-chymotrypsin†

Takashi Matsuo,*a   Chie Imai,a   Takefumi Yoshida,a   Takashi Saito,b   Takashi Hayashib  and  Shun Hirotaa  

* Corresponding authors

a Graduate School of Materials Science, Nara Institute of Science and Technology (NAIST), 8916-5 Takayama-cho, Ikoma, Japan
E-mail: tmatsuo@ms.naist.jp
Fax: +81-743-72-6119
Tel: +81-743-72-6112

b Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Japan

Abstract

An L-phenylalanyl chloromethylketone-based inhibitor equipped with a Hoveyda–Grubbs catalyst moiety was regioselectively incorporated into the cleft of α-chymotrypsin through the intrinsic inhibition mechanism of the protein to construct an artificial organometallic protein.

Graphical abstract: Creation of an artificial metalloprotein with a Hoveyda–Grubbs catalyst moiety through the intrinsic inhibition mechanism of α-chymotrypsin

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Article information

DOI
https://doi.org/10.1039/C2CC16898G
Article type
Communication
Submitted
07 Nov 2011
Accepted
06 Dec 2011
First published
07 Dec 2011

Chem. Commun., 2012,48, 1662-1664

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Creation of an artificial metalloprotein with a Hoveyda–Grubbs catalyst moiety through the intrinsic inhibition mechanism of α-chymotrypsin

T. Matsuo, C. Imai, T. Yoshida, T. Saito, T. Hayashi and S. Hirota, Chem. Commun., 2012, 48, 1662 DOI: 10.1039/C2CC16898G

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