Issue 14, 2012
From the journal:

Chemical Communications

Synthesis of 3,3-disubstituted α-tetralones by rhodium-catalysed reaction of 1-(2-haloaryl)cyclobutanols†

Naoki Ishida,a   Shota Sawanoa  and  Masahiro Murakami*a  

* Corresponding authors

a Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Katsura, Kyoto 615-8510, Japan
E-mail: murakami@sbchem.kyoto-u.ac.jp
Fax: +81 75 383 2748
Tel: +81 75 383 2747

Abstract

The rhodium-catalysed reaction of 1-(2-haloaryl)cyclobutanols afforded 3,3-disubstituted α-tetralones. The reaction was applied to the asymmetric synthesis of α-tetralones bearing a chiral quaternary carbon centre at the 3-position, which was otherwise difficult to execute.

Graphical abstract: Synthesis of 3,3-disubstituted α-tetralones by rhodium-catalysed reaction of 1-(2-haloaryl)cyclobutanols

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Article information

DOI
https://doi.org/10.1039/C2CC16907J
Article type
Communication
Submitted
08 Nov 2011
Accepted
06 Dec 2011
First published
19 Dec 2011

Chem. Commun., 2012,48, 1973-1975

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Synthesis of 3,3-disubstituted α-tetralones by rhodium-catalysed reaction of 1-(2-haloaryl)cyclobutanols

N. Ishida, S. Sawano and M. Murakami, Chem. Commun., 2012, 48, 1973 DOI: 10.1039/C2CC16907J

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