Issue 15, 2012
From the journal:

Chemical Communications

Continuous flow metal-free oxidation of picolines using air†

Masaya Hamano,‡a   Kevin D. Nagy‡b  and  Klavs F. Jensen*b  

* Corresponding authors

a Chemical Process Research Laboratories, Fukui Research Institute, Ono Pharmaceutical Co., Ltd., 50-10 Yamagishi, Mikuni, Sakai, Fukui 913-0032, Japan

b Massachusetts Institute of Technology, Department of Chemical Engineering, Room 66-342, 77 Massachusetts Ave, Cambridge, USA
E-mail: kfjensen@mit.edu
Fax: +1 617-258-8992
Tel: +1 617-253-4589

Abstract

The metal free, direct oxidation of 2-, 3-, and 4-picoline to the corresponding carboxylic acid using either oxygen or air has been developed under continuous flow conditions. Complete conversion for all three substrates was obtained at moderate temperatures and pressures within minutes.

Graphical abstract: Continuous flow metal-free oxidation of picolines using air

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Article information

DOI
https://doi.org/10.1039/C2CC17123F
Article type
Communication
Submitted
16 Nov 2011
Accepted
23 Dec 2011
First published
04 Jan 2012

Chem. Commun., 2012,48, 2086-2088

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Continuous flow metal-free oxidation of picolines using air

M. Hamano, K. D. Nagy and K. F. Jensen, Chem. Commun., 2012, 48, 2086 DOI: 10.1039/C2CC17123F

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