Issue 20, 2012
From the journal:

Chemical Communications

Circular permutation of the starch-binding domain: inversion of ligand selectivity with increased affinity†

Preyesh Stephen,a   Kai-Li Tseng,a   Yu-Nan Liua  and  Ping-Chiang Lyu*a  

* Corresponding authors

a Institute of Bioinformatics and Structural Biology, National Tsing Hua University, No. 101, Sec. 2, Kuang Fu Rd, Hsinchu, Taiwan ROC
E-mail: pclyu@mx.nthu.edu.tw
Fax: +886 35715934
Tel: +886 35742762

Abstract

Proteins containing starch-binding domains (SBDs) are used in a variety of scientific and technological applications. A circularly permutated SBD (CP90) with improved affinity and selectivity toward longer-chain carbohydrates was synthesized, suggesting that a new starch-binding protein may be developed for specific scientific and industrial applications.

Graphical abstract: Circular permutation of the starch-binding domain: inversion of ligand selectivity with increased affinity

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Article information

DOI
https://doi.org/10.1039/C2CC17376J
Article type
Communication
Submitted
25 Nov 2011
Accepted
12 Jan 2012
First published
17 Jan 2012

Chem. Commun., 2012,48, 2612-2614

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Circular permutation of the starch-binding domain: inversion of ligand selectivity with increased affinity

P. Stephen, K. Tseng, Y. Liu and P. Lyu, Chem. Commun., 2012, 48, 2612 DOI: 10.1039/C2CC17376J

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