Issue 27, 2012
From the journal:

Chemical Communications

Probe sialidase substrate specificity using chemoenzymatically synthesized sialosides containing C9-modified sialic acid†

Zahra Khedri,‡a   Musleh M. Muthana,‡a   Yanhong Li,‡a   Saddam M. Muthana,§a   Hai Yu,a   Hongzhi Caoa  and  Xi Chen*a  

* Corresponding authors

a Department of Chemistry, University of California, One Shields Avenue, Davis, USA
E-mail: chen@chem.ucdavis.edu
Fax: +1 530-752-8995
Tel: +1 530-754-6037

Abstract

A library of α2–3- and α2–6-linked sialyl galactosides containing C9-modified sialic acids was synthesized from C6-modified mannose derivatives using an efficient one-pot three-enzyme system. These sialosides were used in a high-throughput sialidase substrate specificity assay to elucidate the importance of C9–OH in sialidase recognition.

Graphical abstract: Probe sialidase substrate specificity using chemoenzymatically synthesized sialosides containing C9-modified sialic acid

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2CC17393J
Article type
Communication
Submitted
27 Nov 2011
Accepted
07 Feb 2012
First published
09 Feb 2012

Chem. Commun., 2012,48, 3357-3359

Permissions

Request permissions

Probe sialidase substrate specificity using chemoenzymatically synthesized sialosides containing C9-modified sialic acid

Z. Khedri, M. M. Muthana, Y. Li, S. M. Muthana, H. Yu, H. Cao and X. Chen, Chem. Commun., 2012, 48, 3357 DOI: 10.1039/C2CC17393J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements