Issue 21, 2012
From the journal:

Chemical Communications

Regioselective zincation of indazoles using TMP2Zn and Negishi cross-coupling with aryl and heteroaryl iodides†

Andreas Unsinna  and  Paul Knochel*a  

* Corresponding authors

a Ludwig Maximilians-Universität München, Department Chemie, Butenandtstraße 5-13, Haus F, 81377 München, Germany
E-mail: paul.knochel@cup.uni-muenchen.de
Fax: +49 089 2180 77680
Tel: +49 089 2180 77681

Abstract

The metalation of various SEM-protected functionalized indazoles with TMP2Zn provides 3-zincated indazoles which undergo palladium-catalyzed Negishi cross-couplings in good yields.

Graphical abstract: Regioselective zincation of indazoles using TMP2Zn and Negishi cross-coupling with aryl and heteroaryl iodides

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Article information

DOI
https://doi.org/10.1039/C2CC17804D
Article type
Communication
Submitted
13 Dec 2011
Accepted
17 Jan 2012
First published
03 Feb 2012

Chem. Commun., 2012,48, 2680-2682

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Regioselective zincation of indazoles using TMP2Zn and Negishi cross-coupling with aryl and heteroaryl iodides

A. Unsinn and P. Knochel, Chem. Commun., 2012, 48, 2680 DOI: 10.1039/C2CC17804D

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