Issue 28, 2012
From the journal:

Chemical Communications

Synthesis of β-cyclodextrin conjugated superparamagnetic iron oxide nanoparticles for selective binding and detection of cholesterol crystals†

Hongguang Li,‡a   Mohammad H. El-Dakdouki,‡a   David C. Zhu,bc   George S. Abelad  and  Xuefei Huang*ac  

* Corresponding authors

a Department of Chemistry, Michigan State University, East Lansing, Michigan, USA
E-mail: xuefei@chemistry.msu.edu
Fax: +1-517-353-1793
Tel: +1-517-355-9715 ext 329

b Departments of Radiology and Psychology, Michigan State University, East Lansing, Michigan, USA

c Biomedical Imaging Research Centre, Michigan State University, East Lansing, Michigan, USA

d Department of Medicine, Division of Cardiology, Michigan State University, East Lansing, Michigan, USA

Abstract

Water-soluble, β-cyclodextrin conjugated superparamagnetic nanoparticles have been constructed. These particles showed selective binding to cholesterol crystals, which opens the door for the detection of cholesterol crystal-related diseases such as atherosclerosis by magnetic resonance imaging (MRI).

Graphical abstract: Synthesis of β-cyclodextrin conjugated superparamagnetic iron oxide nanoparticles for selective binding and detection of cholesterol crystals

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Article information

DOI
https://doi.org/10.1039/C2CC17852D
Article type
Communication
Submitted
15 Dec 2011
Accepted
02 Jan 2012
First published
05 Jan 2012

Chem. Commun., 2012,48, 3385-3387

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Synthesis of β-cyclodextrin conjugated superparamagnetic iron oxide nanoparticles for selective binding and detection of cholesterol crystals

H. Li, M. H. El-Dakdouki, D. C. Zhu, G. S. Abela and X. Huang, Chem. Commun., 2012, 48, 3385 DOI: 10.1039/C2CC17852D

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