Issue 23, 2012
From the journal:

Chemical Communications

A palladium-catalyzed three-component reaction for the preparation of quinazolin-4(3H)-imines†

Guanyinsheng Qiu,a   Gang Liu,ab   Shouzhi Pu*b  and  Jie Wu*ac  

* Corresponding authors

a Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China
E-mail: jie_wu@fudan.edu.cn
Fax: +86 21 6564 1740
Tel: +86 21 6510 2412

b Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science & Technology Normal University, Nanchang 330013, China

c State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China

Abstract

A novel and efficient route for the preparation of quinazolin-4(3H)-imines via a palladium-catalyzed three-component reaction of carbodiimide, isocyanide, and nucleophile is described. The palladium-catalyzed isocyanide insertion is believed to be the key step during the reaction process.

Graphical abstract: A palladium-catalyzed three-component reaction for the preparation of quinazolin-4(3H)-imines

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Article information

DOI
https://doi.org/10.1039/C2CC18001D
Article type
Communication
Submitted
22 Dec 2011
Accepted
25 Jan 2012
First published
25 Jan 2012

Chem. Commun., 2012,48, 2903-2905

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A palladium-catalyzed three-component reaction for the preparation of quinazolin-4(3H)-imines

G. Qiu, G. Liu, S. Pu and J. Wu, Chem. Commun., 2012, 48, 2903 DOI: 10.1039/C2CC18001D

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