Issue 32, 2012

Iron(II)-catalyzed enantioselective meso-epoxide-opening with anilines

Abstract

A highly enantioselective method for the catalytic opening of aromatic meso-epoxides with aniline derivatives was developed. The desired chiral β-amino alcohols were obtained in mostly good to very good yields with excellent enantioselectivities. Structural evidence of the pre-catalyst revealed a scarcely disclosed heptadentate Fe(II) complex with the chiral bipyridine ligand.

Graphical abstract: Iron(II)-catalyzed enantioselective meso-epoxide-opening with anilines

Supplementary files

Article information

Article type
Communication
Submitted
22 Dec 2011
Accepted
26 Jan 2012
First published
27 Jan 2012

Chem. Commun., 2012,48, 3806-3808

Iron(II)-catalyzed enantioselective meso-epoxide-opening with anilines

B. Plancq and T. Ollevier, Chem. Commun., 2012, 48, 3806 DOI: 10.1039/C2CC18032D

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