Issue 47, 2012
From the journal:

Chemical Communications

Disulfide- and terminal alkyne-functionalized magnetic silica particles for enrichment of azido glycopeptides†

Sheng Wang,a   Wenxian Xie,a   Xiu Zhang,a   Xia Zoua  and  Yan Zhang*a  

* Corresponding authors

a Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai 200240, China
E-mail: yanzhang2006@sjtu.edu.cn
Fax: +86-21-34206778
Tel: +86-21-34206778

Abstract

Disulfide- and terminal alkyne-modified magnetic silica particles (DA-MSPs) were synthesized and used to covalently capture and reductively release azido glycopeptides via click chemistry and dithiothreitol treatment. Using DA-MSPs, an efficient and specific enrichment method for separating azido glycopeptides has been developed.

Graphical abstract: Disulfide- and terminal alkyne-functionalized magnetic silica particles for enrichment of azido glycopeptides

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Article information

DOI
https://doi.org/10.1039/C2CC18160F
Article type
Communication
Submitted
30 Dec 2011
Accepted
17 Apr 2012
First published
18 Apr 2012

Chem. Commun., 2012,48, 5907-5909

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Disulfide- and terminal alkyne-functionalized magnetic silica particles for enrichment of azido glycopeptides

S. Wang, W. Xie, X. Zhang, X. Zou and Y. Zhang, Chem. Commun., 2012, 48, 5907 DOI: 10.1039/C2CC18160F

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