Issue 39, 2012
From the journal:

Chemical Communications

Fluorescence turn-on detection of hypochlorous acidvia HOCl-promoted dihydrofluorescein-etheroxidation and its application in vivo†

Yi Zhou,a   Ju-Ying Li,a   Kai-Hui Chu,a   Ke Liu,a   Cheng Yao*a  and  Jing-Yun Lib  

* Corresponding authors

a State Key Laboratory of Materials-Oriented Chemical Engineering and College of Science, Nanjing University of Technology, Nanjing 210009, P. R. China
E-mail: yaochengnjut@126.com
Fax: +86-25-8358-7433

b Animal Model Research Center, Nanjing University, Nanjing 210061, P. R. China

Abstract

We report three new water-soluble dihydrofluorescein-ether probes FCN1, FCN2 and FCN3 for the detection of hypochlorous acid (HOCl), which were designed on the basis of a specific HOCl-promoted oxidation reaction. This work also provided a useful method to monitor the accumulated HOCl in specific organelles using a zebrafish model.

Graphical abstract: Fluorescence turn-on detection of hypochlorous acid via HOCl-promoted dihydrofluorescein-ether oxidation and its application in vivo

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Article information

DOI
https://doi.org/10.1039/C2CC30265A
Article type
Communication
Submitted
12 Jan 2012
Accepted
15 Feb 2012
First published
17 Feb 2012

Chem. Commun., 2012,48, 4677-4679

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Fluorescence turn-on detection of hypochlorous acid via HOCl-promoted dihydrofluorescein-ether oxidation and its application in vivo

Y. Zhou, J. Li, K. Chu, K. Liu, C. Yao and J. Li, Chem. Commun., 2012, 48, 4677 DOI: 10.1039/C2CC30265A

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