Issue 39, 2012
From the journal:

Chemical Communications

Kinetic resolution of 1-(1-alkynyl)cyclopropyl ketones by gold(i)-catalyzed asymmetric [4+3]cycloaddition with nitrones: scope, mechanism and applications†

Yanqing Zhanga  and  Junliang Zhang*ab  

* Corresponding authors

a Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200062, China
E-mail: jlzhang@chem.ecnu.edu.cn

b State key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China

Abstract

Highly useful optically active 1-(1-alkynyl)cyclopropyl ketones can be efficiently obtained by the kinetic resolution of the easily available racemic ones under the catalysis of the chiral gold(I) species. Reaction scope and synthetic applications are also investigated.

Graphical abstract: Kinetic resolution of 1-(1-alkynyl)cyclopropyl ketones by gold(i)-catalyzed asymmetric [4+3]cycloaddition with nitrones: scope, mechanism and applications

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Article information

DOI
https://doi.org/10.1039/C2CC30309D
Article type
Communication
Submitted
14 Jan 2012
Accepted
20 Mar 2012
First published
20 Mar 2012

Chem. Commun., 2012,48, 4710-4712

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Kinetic resolution of 1-(1-alkynyl)cyclopropyl ketones by gold(I)-catalyzed asymmetric [4+3]cycloaddition with nitrones: scope, mechanism and applications

Y. Zhang and J. Zhang, Chem. Commun., 2012, 48, 4710 DOI: 10.1039/C2CC30309D

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