Issue 37, 2012
From the journal:

Chemical Communications

A label-free fluorescence DNA probe based on ligation reaction with quadruplex formation for highly sensitive and selective detection of nicotinamide adenine dinucleotide†

Jingjin Zhao,a   Liangliang Zhang,a   Jianhui Jiang,a   Guoli Shena  and  Ruqin Yu*a  

* Corresponding authors

a State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China
E-mail: rqyu@hnu.edu.cn
Fax: +86 731-88822577
Tel: +86 731-88822577

Abstract

A simple label-free fluorescent sensing scheme for sensitive and selective detection of nicotinamide adenine dinucleotide (NAD+) has been developed based on DNA ligation reaction with ligand-responsive quadruplex formation. This approach can detect 0.5 nM NAD+ with high selectivity against other NAD+ analogs.

Graphical abstract: A label-free fluorescence DNA probe based on ligation reaction with quadruplex formation for highly sensitive and selective detection of nicotinamide adenine dinucleotide

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Article information

DOI
https://doi.org/10.1039/C2CC30540B
Article type
Communication
Submitted
24 Jan 2012
Accepted
27 Feb 2012
First published
28 Feb 2012

Chem. Commun., 2012,48, 4468-4470

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A label-free fluorescence DNA probe based on ligation reaction with quadruplex formation for highly sensitive and selective detection of nicotinamide adenine dinucleotide

J. Zhao, L. Zhang, J. Jiang, G. Shen and R. Yu, Chem. Commun., 2012, 48, 4468 DOI: 10.1039/C2CC30540B

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