Issue 32, 2012
From the journal:

Chemical Communications

A novel synthetic strategy for monosubstituted cyclodextrin derivatives†

Giovanni Di Fabio,*a   Gaetano Malgieri,b   Carla Isernia,b   Jennifer D'Onofrio,a   Maria Gaglione,b   Anna Messere,b   Armando Zarrellia  and  Lorenzo De Napolia  

* Corresponding authors

a Dipartimento di Scienze Chimiche, Università degli Studi di Napoli “Federico II”, Complesso Universitario di Monte S. Angelo, via Cintia, 4, I-80126 Napoli, Italy
E-mail: difabio@unina.it
Fax: +39-081-674393
Tel: +39-081-674001

b Dipartimento di Scienze Ambientali, Seconda Università di Napoli, Via Vivaldi, 43, Caserta, Italy

Abstract

A first solid phase approach to obtain monosubstituted CD conjugates to different labels has been developed. A new solid support has been designed to get a variety of C-6 monofunctionalized CDs (α, β, MeβCD and HPβCD) covalently linked through a phosphodiester bridge to different labels, in highly pure form and under very mild detachment conditions.

Graphical abstract: A novel synthetic strategy for monosubstituted cyclodextrin derivatives

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Article information

DOI
https://doi.org/10.1039/C2CC30550J
Article type
Communication
Submitted
24 Jan 2012
Accepted
23 Feb 2012
First published
24 Feb 2012

Chem. Commun., 2012,48, 3875-3877

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A novel synthetic strategy for monosubstituted cyclodextrin derivatives

G. D. Fabio, G. Malgieri, C. Isernia, J. D'Onofrio, M. Gaglione, A. Messere, A. Zarrelli and L. De Napoli, Chem. Commun., 2012, 48, 3875 DOI: 10.1039/C2CC30550J

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