Issue 35, 2012
From the journal:

Chemical Communications

Live-cell monitoring of the glutathione-triggered release of the anticancer drugtopotecan on gold nanoparticles in serum-containing media†

Mira Kim,a   Kwangsu Ock,a   Keunchang Cho,a   Sang-Woo Joo*a  and  So Yeong Lee*b  

* Corresponding authors

a Department of Soongsil University, Seoul 156-743, Korea
E-mail: sjoo@ssu.ac.kr

b Laboratory of Pharmacology, Seoul National University, Seoul 151-742, Korea
E-mail: leeso@snu.ac.kr

Abstract

The intracellular glutathione-triggered release of the anticancer drug topotecan from gold nanoparticles in serum-containing media was directly monitored in real time using a label-free fluorescence live-cell imaging technique.

Graphical abstract: Live-cell monitoring of the glutathione-triggered release of the anticancer drug topotecan on gold nanoparticles in serum-containing media

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Article information

DOI
https://doi.org/10.1039/C2CC30679D
Article type
Communication
Submitted
31 Jan 2012
Accepted
05 Mar 2012
First published
05 Mar 2012

Chem. Commun., 2012,48, 4205-4207

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Live-cell monitoring of the glutathione-triggered release of the anticancer drug topotecan on gold nanoparticles in serum-containing media

M. Kim, K. Ock, K. Cho, S. Joo and S. Y. Lee, Chem. Commun., 2012, 48, 4205 DOI: 10.1039/C2CC30679D

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