Issue 37, 2012
From the journal:

Chemical Communications

Oxo-ester mediated native chemical ligation on microarrays: an efficient and chemoselective coupling methodology†

Martin J. Weissenborn,‡a   Roberto Castangia,‡a   Johannes W. Wehner,b   Robert Šardzík,a   Thisbe K. Lindhorst*b  and  Sabine L. Flitsch*a  

* Corresponding authors

a School of Chemistry & Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess Street, Manchester M17DN, UK
E-mail: sabine.flitsch@manchester.ac.uk
Fax: +44-(0)161-275-1311
Tel: +44-(0)161-306-5172

b Otto Diels Institute of Organic Chemistry, Christiana Albertina University of Kiel, Otto-Hahn-Platz 3/4, 24098 Kiel, Germany
E-mail: tklind@oc.uni-kiel.de
Fax: +49-431-880-7410

Abstract

We report a highly efficient and selective method for the coupling of peptides and glycoconjugates bearing N-terminal cysteines to activated surfaces. This chemoselective method generates stable amide linkages without using any thiol additives.

Graphical abstract: Oxo-ester mediated native chemical ligation on microarrays: an efficient and chemoselective coupling methodology

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Article information

DOI
https://doi.org/10.1039/C2CC30844D
Article type
Communication
Submitted
06 Feb 2012
Accepted
19 Mar 2012
First published
20 Mar 2012

Chem. Commun., 2012,48, 4444-4446

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Oxo-ester mediated native chemical ligation on microarrays: an efficient and chemoselective coupling methodology

M. J. Weissenborn, R. Castangia, J. W. Wehner, R. Šardzík, T. K. Lindhorst and S. L. Flitsch, Chem. Commun., 2012, 48, 4444 DOI: 10.1039/C2CC30844D

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