Issue 87, 2012
From the journal:

Chemical Communications

I-Motif formation in gene promoters: unusually stable formation in sequences complementary to known G-quadruplexes†

John A. Brazier,*a   Arti Shaha  and  Geoffrey D. Brownb  

* Corresponding authors

a School of Pharmacy, University of Reading, Whiteknights, Reading, Berks
E-mail: j.a.brazier@reading.ac.uk
Fax: +44(0)118 378 4703
Tel: +44(0)118 378 4707

b Department of Chemistry, University of Reading, Whiteknights, Reading, Berks, RG6 6AD

Abstract

I-motif formation has been confirmed in a number of gene promoter sequences known to form G-quadruplex structures. I-motif formation can occur close to physiological temperature and pH for h-tert and PDGF-A. The i-motif structure formed by a HIF-1α promoter sequence shows unexpected stability near neutral pH.

Graphical abstract: I-Motif formation in gene promoters: unusually stable formation in sequences complementary to known G-quadruplexes

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Article information

DOI
https://doi.org/10.1039/C2CC30863K
Article type
Communication
Submitted
07 Feb 2012
Accepted
28 May 2012
First published
29 May 2012

Chem. Commun., 2012,48, 10739-10741

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I-Motif formation in gene promoters: unusually stable formation in sequences complementary to known G-quadruplexes

J. A. Brazier, A. Shah and G. D. Brown, Chem. Commun., 2012, 48, 10739 DOI: 10.1039/C2CC30863K

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