Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu2(μ-terephthalate)(1,10-phen)4]2+

Andreea Prisecaru; Michael Devereux; Niall Barron; Malachy McCann; John Colleran; Alan Casey; Vickie McKee; Andrew Kellett

doi:10.1039/C2CC31023F

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Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu₂(μ-terephthalate)(1,10-phen)₄]²⁺†

Andreea Prisecaru,^a Michael Devereux,^b Niall Barron,^c Malachy McCann,^d John Colleran,^d Alan Casey,^b Vickie McKee^e and Andrew Kellett*^a

Author affiliations

* Corresponding authors

^a School of Chemical Sciences and National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
E-mail: andrew.kellett@dcu.ie, andrew.kellett@gmail.com
Tel: + 353 1 7005461

^b The inorganic pharmaceutical and biomimetic research centre, Focas Research Institute, Dublin Institute of Technology, Camden Row, Dublin 8, Ireland

^c National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland

^d Chemistry Department, National University of Ireland, Maynooth, Co. Kildare, Ireland

^e Department of Chemistry, Loughborough University, Loughborough, Leicestershire, UK

Abstract

The di-copper(II) cation, [Cu₂(μ-terephthalate)(1,10-phen)₄]²⁺, is a powerful, non-sequence-specific, minor-groove oxidizer of duplex DNA which, unlike copper(II) bis-1,10-phenanthroline chloride, operates independently of exogenous reagents. The agent displays excellent in vitro cytoxicity towards cisplatin-resistant ovarian cancer cells, producing intracellular reactive oxygen species upon nano-molar exposure.

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Article information

DOI: https://doi.org/10.1039/C2CC31023F
Article type: Communication
Submitted: 12 Feb 2012
Accepted: 22 May 2012
First published: 23 May 2012

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Chem. Commun., 2012,48, 6906-6908

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Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu₂(μ-terephthalate)(1,10-phen)₄]²⁺

A. Prisecaru, M. Devereux, N. Barron, M. McCann, J. Colleran, A. Casey, V. McKee and A. Kellett, Chem. Commun., 2012, 48, 6906 DOI: 10.1039/C2CC31023F

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