Issue 38, 2012
From the journal:

Chemical Communications

A highly sensitive two-photonfluorescent probe for mitochondrial zinc ions in living tissue†

Na Young Baek,‡a   Cheol Ho Heo,‡a   Chang Su Lim,b   Goutam Masanta,a   Bong Rae Cho*b  and  Hwan Myung Kim*a  

* Corresponding authors

a Division of Energy Systems Research and Molecular Science & Technology Research Center, Ajou University, Suwon, Korea
E-mail: kimhm@ajou.ac.kr
Fax: +82-31-219-1615

b Department of Chemistry, Korea University, 145, Anamro, Sungbuk-gu, Seoul, Korea
E-mail: chobr@korea.ac.kr
Fax: +82-2-3290-3544

Abstract

We report a highly sensitive two-photon probe (SZn2-Mito) which shows a 70-fold two-photon excited fluorescence enhancement in response to Zn2+ and can selectively detect mitochondrial Zn2+ in a rat hippocampal slice at a depth of 100–200 μm by using two-photon microscopy.

Graphical abstract: A highly sensitive two-photon fluorescent probe for mitochondrial zinc ions in living tissue

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Article information

DOI
https://doi.org/10.1039/C2CC31077E
Article type
Communication
Submitted
14 Feb 2012
Accepted
09 Mar 2012
First published
09 Mar 2012

Chem. Commun., 2012,48, 4546-4548

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A highly sensitive two-photon fluorescent probe for mitochondrial zinc ions in living tissue

N. Y. Baek, C. H. Heo, C. S. Lim, G. Masanta, B. R. Cho and H. M. Kim, Chem. Commun., 2012, 48, 4546 DOI: 10.1039/C2CC31077E

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