Issue 70, 2012

The prenylated dioxopiperazine alkaloid Cristatin A has selective telomeric DNA G-quadruplex stabilising properties

Abstract

Cristatin A (1a/b), a prenylated dioxopiperazine alkaloid, has been shown to bind selectively to telomeric quadruplex DNA using a FRET-based DNA melting assay. Crucially, the molecule is more drug-like than most previously identified quadruplex-binding agents, and provides a unique chemical scaffold for future chemical biology and drug discovery studies.

Graphical abstract: The prenylated dioxopiperazine alkaloid Cristatin A has selective telomeric DNA G-quadruplex stabilising properties

Supplementary files

Article information

Article type
Communication
Submitted
20 Feb 2012
Accepted
06 Jul 2012
First published
06 Jul 2012

Chem. Commun., 2012,48, 8760-8762

The prenylated dioxopiperazine alkaloid Cristatin A has selective telomeric DNA G-quadruplex stabilising properties

K. M. Rahman, M. D. Hossain, M. H. Sohrab, A. F. Drake, T. T. Bui, J. Husby, M. Gunaratnam, S. Neidle, C. M. Hasan and D. E. Thurston, Chem. Commun., 2012, 48, 8760 DOI: 10.1039/C2CC31277H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements