Issue 45, 2012

Formation of CC-type palladacycles with assistance from an apparently innocent NH(CO) functional group

Abstract

A novel cyclometalation pathway to form CC-type palladacycles is reported. Unlike common donor-assisted cyclometalation, the NH(CO) auxiliary group undergoes a deprotonation step to form a palladalactam intermediate. The coordinating nitrogen atom functions as an intramolecular base promoting selective C–H bond cleavage. Without the NH proton, the ortho-N-phenyl C–H is activated instead.

Graphical abstract: Formation of CC-type palladacycles with assistance from an apparently innocent NH(CO) functional group

Supplementary files

Article information

Article type
Communication
Submitted
21 Feb 2012
Accepted
05 Apr 2012
First published
10 Apr 2012

Chem. Commun., 2012,48, 5632-5634

Formation of CC-type palladacycles with assistance from an apparently innocent NH(CO) functional group

J. Lee, Y. Huang, S. Liu, S. Cheng, Y. Jhou, J. Lii and H. M. Lee, Chem. Commun., 2012, 48, 5632 DOI: 10.1039/C2CC31299A

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