Issue 38, 2012
From the journal:

Chemical Communications

The effects of a multifunctional oligomer and its incorporation strategies on the gene delivery efficiency of poly(l-lysine)†

Dezhong Zhou,a   Congxin Li,a   Yuling Hu,a   Hao Zhou,b   Jiatong Chen,b   Zhengpu Zhanga  and  Tianying Guo*a  

* Corresponding authors

a Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Weijin Road, No. 94, Tianjin, China
E-mail: tyguo@nankai.edu.cn
Fax: +86-22-23501597
Tel: +86-22-23501597

b Department of Biochemistry and Molecular Biology, College of Life Science, Nankai University, Weijin Road, No. 94, Tianjin, China

Abstract

A novel multifunctional oligomer is synthesized and incorporated to enhance the gene delivery efficiency of PLL via non-electrostatic assembly and covalent grafting strategies. The improvement of the gene delivery efficiency is dependent on the gene carrying complex properties, and the properties are dependent on the oligomer incorporation strategy.

Graphical abstract: The effects of a multifunctional oligomer and its incorporation strategies on the gene delivery efficiency of poly(l-lysine)

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Article information

DOI
https://doi.org/10.1039/C2CC31359F
Article type
Communication
Submitted
23 Feb 2012
Accepted
15 Mar 2012
First published
15 Mar 2012

Chem. Commun., 2012,48, 4594-4596

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The effects of a multifunctional oligomer and its incorporation strategies on the gene delivery efficiency of poly(L-lysine)

D. Zhou, C. Li, Y. Hu, H. Zhou, J. Chen, Z. Zhang and T. Guo, Chem. Commun., 2012, 48, 4594 DOI: 10.1039/C2CC31359F

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