Issue 41, 2012

Cascade signal amplification strategy for the detection of cancer cells by rolling circle amplification and nanoparticles tagging

Abstract

A cascade signal amplification strategy was proposed for detection of cancer cells at ultralow concentration by combining the rolling circle amplification (RCA) technique with oligonucleotide functionalized nanoparticles (NPs), and anodic stripping voltammetric detection. This flexible biosensing system exhibited high sensitivity and specificity with the detection limits of 10 Ramos cells mL−1.

Graphical abstract: Cascade signal amplification strategy for the detection of cancer cells by rolling circle amplification and nanoparticles tagging

Supplementary files

Article information

Article type
Communication
Submitted
24 Feb 2012
Accepted
29 Mar 2012
First published
30 Mar 2012

Chem. Commun., 2012,48, 5019-5021

Cascade signal amplification strategy for the detection of cancer cells by rolling circle amplification and nanoparticles tagging

C. Ding, H. Liu, N. Wang and Z. Wang, Chem. Commun., 2012, 48, 5019 DOI: 10.1039/C2CC31390A

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