An ultrasensitive electrochemical impedance sensor for a special BRCA1 breast cancer gene sequence based on lambda exonuclease assisted target recycling amplification

Huifeng Xu; Lili Wang; Hongzhi Ye; Lishuang Yu; Xi Zhu; Zhenyu Lin; Guangwen Wu; Xihai Li; Xianxiang Liu; Guonan Chen

doi:10.1039/C2CC31588B

An ultrasensitive electrochemical impedance sensor for a special BRCA1 breast cancer gene sequence based on lambda exonuclease assisted target recycling amplification†

Huifeng Xu,^ab Lili Wang,^ab Hongzhi Ye,^a Lishuang Yu,^a Xi Zhu,^b Zhenyu Lin,^b Guangwen Wu,^a Xihai Li,^a Xianxiang Liu*^a and Guonan Chen*^b

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* Corresponding authors

^a Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, P. R. China
E-mail: liuxianxiang@163.com

^b Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou, P. R. China
E-mail: gnchen@fzu.edu.cn
Fax: +86-591-22866135
Tel: +86-591-22866135

Abstract

A label-free, target recycling electrochemical impedance spectroscopy (EIS) DNA sensor has been developed for detection of a model related to the BRCA1 breast cancer gene with a detection limit of 0.05 nM.

Chemical Communications

An ultrasensitive electrochemical impedance sensor for a special BRCA1 breast cancer gene sequence based on lambda exonuclease assisted target recycling amplification†

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An ultrasensitive electrochemical impedance sensor for a special BRCA1 breast cancer gene sequence based on lambda exonuclease assisted target recycling amplification

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