Issue 46, 2012
From the journal:

Chemical Communications

Synthesis and X-ray structure analysis of a heptacoordinate titanium(iv)-bis-chelate with enhanced in vivo antitumor efficacy†

Timo A. Immel,a   Martin Grützke,a   Anne-Katrin Späte,a   Ulrich Groth,a   Peter Öhlschläger*b  and  Thomas Huhn*a  

* Corresponding authors

a Fachbereich Chemie and Konstanz Research School Chemical Biology, Universität Konstanz, Universitätsstr. 10, D-78457 Konstanz, Germany
E-mail: thomas.huhn@uni-konstanz.de
Fax: +49-7531-884424
Tel: +49-7531-882283

b Fachbereich Chemie und Biotechnologie, Fachhochschule Aachen, Heinrich-Mußmann-Str., D-52428 Jülich, Germany
E-mail: oehlschlaeger@fh-aachen.de

Abstract

Chelate stabilization of a titanium(IV)–salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.

Graphical abstract: Synthesis and X-ray structure analysis of a heptacoordinate titanium(iv)-bis-chelate with enhanced in vivo antitumor efficacy

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Article information

DOI
https://doi.org/10.1039/C2CC31624B
Article type
Communication
Submitted
04 Mar 2012
Accepted
16 Apr 2012
First published
17 Apr 2012

Chem. Commun., 2012,48, 5790-5792

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Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy

T. A. Immel, M. Grützke, A. Späte, U. Groth, P. Öhlschläger and T. Huhn, Chem. Commun., 2012, 48, 5790 DOI: 10.1039/C2CC31624B

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