Issue 45, 2012
From the journal:

Chemical Communications

In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues†

Diana Matthes,a   Lennart Richter,a   Jane Müller,a   Alexander Denisiuk,a   Sven C. Feifel,a   Yuquan Xu,b   Patricia Espinosa-Artiles,b   Roderich D. Süssmuth*a  and  István Molnár*b  

* Corresponding authors

a Technische Universität Berlin, Institut für Chemie, Straße des 17. Juni 124, 10623 Berlin, Germany
E-mail: suessmuth@chem.tu-berlin.de

b SW Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, The University of Arizona, 250 E. Valencia Rd., Tucson, USA
E-mail: imolnar@email.arizona.edu

Abstract

New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strain expressing the bbBeas gene.

Graphical abstract: In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

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Article information

DOI
https://doi.org/10.1039/C2CC31669B
Article type
Communication
Submitted
06 Mar 2012
Accepted
17 Apr 2012
First published
01 May 2012

Chem. Commun., 2012,48, 5674-5676

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In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

D. Matthes, L. Richter, J. Müller, A. Denisiuk, S. C. Feifel, Y. Xu, P. Espinosa-Artiles, R. D. Süssmuth and I. Molnár, Chem. Commun., 2012, 48, 5674 DOI: 10.1039/C2CC31669B

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