CO2 gas induced drug release from pH-sensitive liposome to circumvent doxorubicin resistant cells

Abstract

A novel pH-sensitive liposome encapsulating doxorubicin was prepared by a NH₄HCO₃ gradient method. The liposomes were able to release the drug at pH 5.0 by the production of CO₂ gas. More importantly, the drug-loaded liposome effectively circumvented the breast cancer cells resistant to doxorubicin.