Issue 51, 2012
From the journal:

Chemical Communications

DNA-based catalytic enantioselective intermolecular oxa-Michael addition reactions†

Rik P. Megensa  and  Gerard Roelfes*a  

* Corresponding authors

a Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, The Netherlands
E-mail: j.g.roelfes@rug.nl
Web: http//roelfes.fmns.rug.nl
Fax: +31 50-363-4296

Abstract

Using the DNA-based catalysis concept, a novel Cu(II) catalyzed enantioselective oxa-Michael addition of alcohols to enones is reported. Enantioselectivities of up to 86% were obtained. The presence of water is important for the reactivity, possibly by reverting unwanted side reactions such as 1,2-additions.

Graphical abstract: DNA-based catalytic enantioselective intermolecular oxa-Michael addition reactions

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Article information

DOI
https://doi.org/10.1039/C2CC31854G
Article type
Communication
Submitted
13 Mar 2012
Accepted
08 May 2012
First published
08 May 2012

Chem. Commun., 2012,48, 6366-6368

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DNA-based catalytic enantioselective intermolecular oxa-Michael addition reactions

R. P. Megens and G. Roelfes, Chem. Commun., 2012, 48, 6366 DOI: 10.1039/C2CC31854G

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