Issue 43, 2012

An unprecedented ring-opening reaction of N-(aziridin-2-ylmethylene)hydrazines to facile synthesis of functionalized enamines catalysed by Lewis acid

Abstract

An interesting Lewis acid-catalysed ring-opening reaction of N-(aziridin-2-ylmethylene)hydrazines has been described in this context. A variety of functionalized enamines could be obtained in good yields through a highly regioselective cleavage of a carbon–nitrogen single bond in the aziridines along with a 1,2-migration of the substituent.

Graphical abstract: An unprecedented ring-opening reaction of N-(aziridin-2-ylmethylene)hydrazines to facile synthesis of functionalized enamines catalysed by Lewis acid

Supplementary files

Article information

Article type
Communication
Submitted
15 Mar 2012
Accepted
03 Apr 2012
First published
04 Apr 2012

Chem. Commun., 2012,48, 5334-5336

An unprecedented ring-opening reaction of N-(aziridin-2-ylmethylene)hydrazines to facile synthesis of functionalized enamines catalysed by Lewis acid

Z. Zhang, Y. Wei and M. Shi, Chem. Commun., 2012, 48, 5334 DOI: 10.1039/C2CC31911J

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