Issue 53, 2012
From the journal:

Chemical Communications

A biocatalytic redox isomerisation†‡

Serena Gargiulo,a   Diederik J. Opperman,b   Ulf Hanefeld,a   Isabel W. C. E. Arendsa  and  Frank Hollmann*a  

* Corresponding authors

a Department of Biotechnology, Delft University of Technology, Julianalaan 136, 2628BL Delft, The Netherlands
E-mail: f.hollmann@tudelft.nl
Fax: +31-152781415
Tel: +31-152781957

b Microbial, Biochemical and Food Biotechnology, University of the Free State, Bloemfontein, South Africa

Abstract

A bi-enzymatic cascade for the redox-isomerisation of allylic alcohol is presented. Coupling of an alcohol dehydrogenase to an enoate reductase has been successfully applied in one pot for the isomerisation of an allylic alcohol to the corresponding ketone. Critical parameters for yield and selectivity have been investigated.

Graphical abstract: A biocatalytic redox isomerisation

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Article information

DOI
https://doi.org/10.1039/C2CC31947K
Article type
Communication
Submitted
16 Mar 2012
Accepted
18 Apr 2012
First published
18 Apr 2012

Chem. Commun., 2012,48, 6630-6632

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A biocatalytic redox isomerisation

S. Gargiulo, D. J. Opperman, U. Hanefeld, I. W. C. E. Arends and F. Hollmann, Chem. Commun., 2012, 48, 6630 DOI: 10.1039/C2CC31947K

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