Issue 48, 2012

Click–click chemistry on a peptidic scaffold for easy access to tetrameric DNA structures

Abstract

The use of a peptidic template and orthogonal oxime ligation and CuAAC reaction allows a stepwise approach for the design of antiparallel tetrameric DNA structure. As a proof of concept template assisted synthesis of i-motif DNA was achieved. As anticipated, a dramatic improvement in the stability of such a tetrameric structure was observed. More interestingly the formation of the i-motif was still observed at neutral pH, which could be attributed to the spatial proximity of the basic centers.

Graphical abstract: Click–click chemistry on a peptidic scaffold for easy access to tetrameric DNA structures

Supplementary files

Article information

Article type
Communication
Submitted
19 Mar 2012
Accepted
23 Apr 2012
First published
24 Apr 2012

Chem. Commun., 2012,48, 5992-5994

Click–click chemistry on a peptidic scaffold for easy access to tetrameric DNA structures

R. Bonnet, P. Murat, N. Spinelli and E. Defrancq, Chem. Commun., 2012, 48, 5992 DOI: 10.1039/C2CC32010J

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