Rapid and high-yielding cysteine labelling of peptides with N-succinimidyl 4-[18F]fluorobenzoate

Sergio Abad; Pau Nolis; Juan D. Gispert; Jan Spengler; Fernando Albericio; Santiago Rojas; José R. Herance

doi:10.1039/C2CC32095A

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Rapid and high-yielding cysteine labelling of peptides with N-succinimidyl 4-[¹⁸F]fluorobenzoate†‡

Sergio Abad,*^a Pau Nolis,^b Juan D. Gispert,^c Jan Spengler,^d Fernando Albericio,^d Santiago Rojas^ac and José R. Herance*^ac

Author affiliations

* Corresponding authors

^a Centre d'Imatge Molecular, CRC Corporació Sanitària, Dr Aigüader 88, 08003 Barcelona, Spain
E-mail: sabad@crccorp.es
Fax: +34 935511601
Tel: +34 935511605

^b Servei de Ressonància Magnètica Nuclear, Universitat Autonòma de Barcelona, 08193 Bellaterra, Spain

^c Fundació Privada Institut d'Alta Tecnologia-Parc de Recerca Biomèdica de Barcelona, 08003 Barcelona, Spain
E-mail: rherance@crccorp.es
Fax: +34 935511601
Tel: +34 935511600

^d Institute for Research in Biomedicine, CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Barcelona Science Park, 08028 Barcelona, Spain

Abstract

Fast cysteine labelling of peptides promoted by an adjacent arginine has been observed with a standard labelling agent specific for amines, N-succinimidyl 4-[¹⁸F]fluorobenzoate.

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Article information

DOI: https://doi.org/10.1039/C2CC32095A
Article type: Communication
Submitted: 22 Mar 2012
Accepted: 27 Apr 2012
First published: 27 Apr 2012

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Chem. Commun., 2012,48, 6118-6120

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Rapid and high-yielding cysteine labelling of peptides with N-succinimidyl 4-[¹⁸F]fluorobenzoate

S. Abad, P. Nolis, J. D. Gispert, J. Spengler, F. Albericio, S. Rojas and J. R. Herance, Chem. Commun., 2012, 48, 6118 DOI: 10.1039/C2CC32095A

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Chemical Communications