A robust, modular fluorogenic probe system has been developed which allows the highly sensitive off–ON detection of aminopeptidase activity by releasing an exceptionally photostable, insoluble, phenolic ESIPT fluorophore. The probes generate no false positive signal in over 24 hours, but when activated give a signal within 10 minutes.
O. Thorn-Seshold, M. Vargas-Sanchez, S. McKeon and J. Hasserodt, Chem. Commun., 2012, 48, 6253 DOI: 10.1039/C2CC32227G
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