Issue 52, 2012
From the journal:

Chemical Communications

Click and photo-unclick chemistry of aminoacrylate for visible light-triggered drug release†

Moses Bio,ab   Gregory Nkepangab  and  Youngjae You*ab  

* Corresponding authors

a Department of Pharmaceutical Sciences, University of Oklahoma, Oklahoma City, OK 73117, USA
E-mail: youngjae-you@ouhsc.edu
Fax: +1-405-271-7505
Tel: +1-405-271-6593 x47473

b Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA

Abstract

“Click and Photo-unclick Chemistry” of aminoacrylates is proposed for a new photo-labile linker. Adducts are built in 2 steps with good yields and cleaved rapidly by tissue penetrable visible light (690 nm) with a photosensitizer. Facile synthesis, release of mother drug, and stability and cleavage in medium are demonstrated.

Graphical abstract: Click and photo-unclick chemistry of aminoacrylate for visible light-triggered drug release

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Article information

DOI
https://doi.org/10.1039/C2CC32373G
Article type
Communication
Submitted
02 Apr 2012
Accepted
04 May 2012
First published
23 May 2012

Chem. Commun., 2012,48, 6517-6519

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Click and photo-unclick chemistry of aminoacrylate for visible light-triggered drug release

M. Bio, G. Nkepang and Y. You, Chem. Commun., 2012, 48, 6517 DOI: 10.1039/C2CC32373G

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